Tranzyme Inc said a preliminary analysis showed that its experimental
drug to treat a type of paralysis of the stomach did not meet the main goal of
a mid-stage trial. The main goal of the study was to reduce four symptoms in
patients suffering from gastroparesis - a condition that slows down the
movement of food through the digestive tract due to the paralysis of stomach
muscles.
The trial was studying two doses of the drug, TZP-102, administered once
a day for 12 weeks on diabetes patients. The drug was well tolerated, the
company said. This setback comes after the company's experimental drug to
improve gastrointestinal recovery after surgery failed to meet the main goals
of a second late-stage trial in May. The company had said at the time that it
would focus on its drug to treat diabetic gastroparesis.
Tranzyme is currently conducting a second mid-stage trial testing a 10
mg dose of TZP-102 administered thrice daily. Shares of the company, which have
risen about 23 percent since late May, closed at $3.97 on Wednesday on the
Nasdaq.
Source: Chicago Tribune
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