Logo of Swiss pharmaceutical company Roche is pictured in Rotkreuz (MICHAEL BUHOLZER, REUTERS / November 17, 2012)
Swiss drugmaker Roche's cancer drug Avastin failed to make a statistically significant difference to survival rates of patients with a common form of brain cancer in a late-stage study, the company said on Saturday. The Phase III AVAglio study presented at the Society for Neuro-Oncology congress in Washington on Saturday showed Avastin, combined with radiation and chemotherapy, reduced the risk of cancer worsening or death, the Basel-based drugmaker said in a news release.
But the drug did not reach statistical significance in overall survival, a key data point. Further data are expected next year, Roche said. "The interim results for overall survival (OS), the other co-primary endpoint, did not reach statistical significance," the company said in the statement. Earlier data from the study published in August showed Avastin significantly extended progression-free survival of people with an aggressive form of brain cancer. Avastin is Roche's third-biggest seller and is approved to treat several types of cancer, including breast, kidney, colorectal and ovarian cancers.
Source: Chicago Tribune